04方向导师-华大生命中心

刘欢    研究员

姓名:刘欢
导师资格:作物学、农艺与种业
Email: liuhuan@genomics.cn
地址:广东省深圳市大鹏新区国家基因库
个人简介

刘欢,研究员,中国科学院大学研究生导师。深圳华大生命科学研究院生物多样性首席科学家,农业基因组学国家重点实验室副主任,农村农业部农业基因组学重点实验室主任,国家重点研发计划课题负责人,国家药品监督管理局药品快速检测重点实验室学科带头人。BEAT365唯一官网研究生联合导师,华南农业大学兼职教授研究生导师,西北农林科技大学研究生导师广东省植物学会常务理事,广东省“一带一路”农业科教创新联盟副理事长,中国野生动物保护协会保护基因专业委员会委员。

主要从事动植物演化基因组学,农业基因组学,作物群体遗传学,作物根系微生物互作,作物单细胞与时空组学等大科学研究领域。

主持国家重点研发计划“中医药现代化”项目、云南省重大科技专项计划“生物资源数字化开发应用”,岭南现代农业广东省实验室“主粮作物种子时空图谱与发育研究”等多项国家、省部级科研项目。

近年来以一作或通讯(含共同)在Nature Genetics, Nature Ecology & Evolution, Nature Plants3篇), Nature Communications4篇), Molecular Plant2篇), Science Bulletin, Microbiome, Genome Biology, Nucleic Acids Research, New Phytologist3篇), GigaScience2篇), Molecular Ecology Resources3篇), Communicatoins Biogloy2篇), iScienceSCI期刊发表50多篇;其中封面故事文章4篇,Nature Plants, New Phytologist, Molecular Ecology Resources, iScience等期刊封面文章各1篇。其研究成果3次被Nature Plants期刊选为研究亮点发表评论文章1次被Nature Ecology & Evolution期刊选为研究亮点发表评论文章。申请专利25项,其中授权9;主持及参与政府科研项目16项,其中主持4项,联合主持1项;参编著作2

获得多项奖励荣誉,第十一届梁希科学技术奖(2023),深圳市高层次地方级领军人才(2019),深圳市盐田区凤凰梧桐B类人才(2019),中国精品科技期刊顶尖论文—F50002015),深圳市盐田区生物产业高级人才(2013)等荣誉奖励。Frontiers in Plant Science 期刊编委,Molecular Plant, The Plant Journal, Genome Biology and Evolution, Food Microbiology, Horticulture Research等众多国际期刊审稿人。科研成果被中国科技日报、新华社、中央人民政府网站等核心媒体报道。


代表性论文

1. Xing Guo, Fang Wang, Dongming Fang, Qiongqiong Lin, Sunil Kumar Sahu, Liuming Luo, Jiani Li, Yewen Chen, Shanshan Dong, Sisi Chen, Yang Liu, Shixiao Luo, Yalong Guo, Huan Liu . The genome of Acorus deciphers new insights into early monocot evolution. Nature Communications. (2023)14:3662

2. Sunil Kumar Sahu, Huan Liu. A genetic solution for the global food security crisis. Journal of Integrative Plant Biology. (2023)

3. Sunil Kumar Sahu, Huan Liu. Long-read sequencing (method of the year 2022): the way forward for plant omics research. Molecular Plant. (2023) S1674205223001053

4. Jianmu Su, Yayu Wang, Mei Bai, Tianhua Peng, Huisi Li, Hui‐Juan Xu, Guifang Guo, Haiyi Bai, Ning Rong, Sunil Kumar Sahu, Hanjun He, Xiangxiu Liang, Canzhi Jin, Wei Liu, Mikael Lenz Strube, Lone Gram, Yongtao Li, Ertao Wang, Huan Liu* and Hong Wu*. Soil conditions and the plant microbiome boost the accumulation of monoterpenes in the fruit of Citrus reticulata ‘Chachi’. Microbiome. (2023) 11:61

5. Jin Xu, Yayu Wang, Yunzeng Zhang, Nadia Riera, Jinyun Li, Kelley J Clark, Tao Jin, Hongyun Chen, Jiawen Wen, Wenbo Ma, Huan Liu*, and Nian Wang*. Host genetic traits underlying the composition/assembly of the citrus microbiome. Phytobiomes Journal. 2023.02

6. Lin Xian, Sunil Kumar Sahu, Liying Huang, Yannan Fan, Jianhao Lin, Jianmu Su, Mei Bai, Yewen Chen, Shujie Wang, Peng Ye, Fang Wang, Qun Luo, Haiyi Bai, Xiaojing Lin, Caihong Yuan, Xiaodie Geng, Huan Liu*, Hong Wu*. The draft genome and multi-omics analyses reveal new insights into geo-herbalism properties of Citrus grandis ‘Tomentosa’. Plant Science. 325 (2022) 111489.

7. Jing Wang, Jingjing Xie, Haixia Chen, Xia Qiu, Hai Cui, Yijiang Liu, Sunil Kumar Sahu , Dongming Fang, Tengyan Li, Mei Wang, Yewen Chen, Huan Liu*, Jianyong Zhang*, Binbin Wang* . A draft genome of the medicinal plant Cremastra appendiculata (D. Don) provides insights into the colchicine biosynthetic pathway. Communicatoins Biogloy. (2022)5:1294

8. Tianming Lan, Haimeng Li, Shangchen Yang, Minhui Shi, Lei Han, Sunil Kumar Sahu, Yaxian Lu, Jiangang Wang, Mengchao Zhou, Hui Liu, Junxuan Huang, Qing Wang, Yixin Zhu, Li Wang, Yanchun Xu*, Chuyu Lin*, Huan Liu*, and Zhijun Hou*. The chromosome-scale genome of the raccoon dog: Insights into its evolutionary characteristics. iScience. 封面 25, 105117, 2022

9. Yayu Wang, Xiaolin Wang, Shuai Sun, Canzhi Jin, Jianmu Su, Jinpu Wei, Xinyue Luo, Jiawen Wen, Tong Wei, Sunil Kumar Sahu, Hongfeng Zou, Hongyun Chen, Zhixin Mu, Gengyun Zhang, Xin Liu, Xun Xu, Lone Gram, Huanming Yang, Ertao Wang*, Huan Liu*. GWAS, MWAS and mGWAS provide insights into precision agriculture based on genotype-dependent microbial effects in foxtail millet. Nature Communications. (2022)13:5913

10. Qing Wang, Tianming Lan, haimeng li, Yixin Zhu, Minhui Shi, Lei Han, Shangchen Yang, Qian Li, Le Zhang, Sunil Kumar Sahu, Huan Liu*, Yan Hua*. Genomic consequences and large genetic differentiation of extremely threatened Chinese pangolins in Southern China. Communications Biology.

11. Shangchen Yang, Tianming Lan, Yi Zhang, Qing Wang, Haimeng Li, Nicolas Dussex,  Sunil Kumar Sahu, Minhui Shi, Mengyuan Hu, Yixin Zhu, Jun Cao, Lirong Liu, Jianqing Lin,  Qiu-hong Wan, Huan Liu*, Sheng-Guo Fang*. Genomic investigation of the Chinese alligator reveals wild-extinct genetic diversity and genomic consequences of their continuous decline. Molecular Ecology Resources, 封面 2022

12. Le Zhang, Tianming Lan, Chuyu Lin, Wenyuan Fu, Yaohua Yuan, Kaixiong Lin, Haimeng, Li, Sunil Sahu, Zhaoyang Liu, Daqing Chen, Qunxiu Liu, Aishan Wang, Xiaohong Wang, Yue Ma,  Shizhou Li, Yixin Zhu, Xingzhuo Wang, Xiaotong Ren, Haorong Lu, Yunting Huang, Jieyao Yu, Boyang Liu, Qing Wang, Shaofang Zhang, Xun Xu, Huanming Yang, Dan Liu, Huan Liu*, Yanchun Xu*. Chromosome-scale genomes reveal genomic consequences of inbreeding in the South China tiger: a comparative study with the Amur tiger. Molecular Ecology Resources. 2022;00:1–18.

13. Yang Liu , Sibo Wang, Linzhou Li, Ting Yang, Shanshan Dong, Tong Wei, Shengdan Wu , Yongbo Liu, Yiqing Gong, Xiuyan Feng, Jianchao Ma, Guanxiao Chang, Jinling Huang, Yong Yang, Hongli Wang, Min Liu, Yan Xu, Hongping Liang , Jin Yu , Yuqing Cai, Zhaowu Zhang, Yannan Fan , Weixue Mu, Sunil Kumar Sahu, Shuchun Liu, Xiaoan Lang, Leilei Yang, Na Li, Sadaf Habib, Yongqiong Yang, Anders J. Lindstrom , Pei Liang, Bernard Goffinet , Sumaira Zaman, Jill L. Wegrzyn, Dexiang Li, Jian Liu, Jie Cui , Eva C. Sonnenschein , Xiaobo Wang , Jue Ruan , Jia-Yu Xue, Zhu-Qing Shao, Chi Song , Guangyi Fan, Zhen Li, Liangsheng Zhang, Jianquan Liu , Zhong-Jian Liu , Yuannian Jiao , Xiao-Quan Wang , Hong Wu, Ertao Wang, Michael Lisby , Huanming Yang, Jian Wang, Xin Liu , Xun Xu , Nan Li, Pamela S. Soltis , Yves Van de Peer, Douglas E. Soltis*, Xun Gong* , Huan Liu*, Shouzhou Zhang*. Cycad genome and the early evolution of seed plants. Nature Plants, 2022,8(4):389-401. 高被引

14. Yan Xu, Hongli Wang, Sunil Kumar Sahu, Linzhou Li, Hongping Liang, Gerd Günther,  Gane Ka-Shu Wong, Barbara Melkonian, Michael Melkonian, Huan Liu*, Sibo Wang*. Chromosome-level genome of Pedinomonas minor (Chlorophyta) unveils adaptations to abiotic stress in rapidly fluctuating environment. New Phytologist, 2022.

15. Zefeng Wu, Hongyun Chen, Ya Pan, Huan Feng, Dongming Fang, Jun Yang, Yayu Wang, Jun Yang, Sunil Kumar Sahu, Jianling Liu, Yu'e Xing, Xiaolin Wang, Min Liu, Xinyue Luo, Peng Gao, Lifeng Li, Zhongjian Liu, Huanming Yang, Xin Liu, Xun Xu, Huan Liu*, Ertao Wang*. The Genome of Hippophae rhamnoides provides insights into symbiotic nitrogen fixation by Actinomycete. New Phytologist, 2022.

16. Lingfei Li, Xiaoli Chen, Dongming Fang, Shanshan Dong, Xing Guo, Na Li, Lucia Campos-Dominguez, Wenguang Wang, Yang Liu, Xiaoan Lang,  Yang Peng, Daike Tian, Daniel C. Thomas, Weixue Mu, Min Liu, Ting Yang,  uzhou Zhang, Leilei Yang, Jianfen Yang, Zhongjian Liu, Liangsheng Zhang, Xingtan Zhang, Fei Chen, Yuannian Jiao, Yalong Guo, Mark Hughes, Wei Wang, Xiaofei Liu, Chunmei Zhong, Airong Li, Sunil Kumar Sahu, Huanming Yang, Xun Xu, Xin Liu, Ernest Wu, Michael Lisay, Douglas E. Soltis, Yves Van de Peer, Catherine Kidner, Shouzhou Zhang*, Huan Liu*. Genome dynamics underlies diversity of adapted plant Begonia.  New Phytologist, 2022,234(1):295-310.

17. Lei Han, Tianming Lan, Desheng Li, Haimeng Li, Linhua Deng, Zhiwei Peng, Shaowen He, Yanqiang Zhou, Ruobing Han, Lingling Li, Yaxian Lu, Haorong Lu, Qing Wang, Shangchen Yang, Yixin Zhu, Yunting Huang, Xiaofang Cheng, Jieyao Yu, Yulong Wang, Heting Sun, Hongliang Chai, Huanming Yang, Xun Xu, Michael Lisby, Quan Liu, Karsten Kristiansen, Huan Liu*, Zhijun Hou*. Chromosome-scale assembly and whole-genome sequencing of 266 giant panda roundworms provide insights into their evolution, adaptation and potential drug targets. Molecular Ecology Resources, 2022, 22(2):768-785.

18. Sibo Wang, Hongping Liang, Hongli Wang, Linzhou Li, Yan Xu, Yang Liu, Min Liu, Jinpu Wei, Tao Ma, Cheng Le, Jinlong Yang, Chengzhong He, Jie Liu, Jianming Zhao, Yuxian Zhao,  Michael Lisby, Sunil Kumar Sahu*, Huan Liu*. The chromosome-scale genomes of Dipterocarpus turbinatus and Hopea hainanensis (Dipterocarpaceae) provide insights into fragrant oleoresin biosynthesis and hard wood formation. Plant Biotechnology Journal, 2022,20(3):538-553.

19. Dongsheng Chen, Cong Tan, Peiwen Ding, Lihua Luo, Jiacheng Zhu, Xiaosen Jiang, Zhihua Ou, Xiangning Ding, Tianming Lan, Yixin Zhu, Yi Jia, Yanan Wei, Runchu Li, Qiuyu Qin,  Chengcheng Sun, Wandong Zhao, Zhiyuan Lv, Haoyu Wang, Wendi Wu, Yuting Yuan, Mingyi Pu, Yuejiao Li, Yanan Zhang, Xiaoling Wang, Ashley Chang, Yong Bai*, Huan Liu*. VThunter: a database for single-cell screening of virus target cells in animal kingdom. Nucleic Acids Research, 2022,50(D1):D934-D942.

20. Xing Guo, Dongming Fang, Sunil Kumar Sahu, Shuai Yang, Xuanmin Guang, Ryan Folk, Stephen Smith, Andre S. Chanderbali, Sisi Chen, Min Liu, Ting Yang, Shouzhou Zhang, Xin Liu, Xun Xu, Pamela S. Soltis, Douglas E.Soltis*, Huan Liu*. Chloranthus genome provides insights into the early diversification of angiosperms. Nature Communications, 2021,12:6930.

21. Xiaolin Wang, Huan Feng,  Mingxing Wang, Yayu Wang,  Xingguang Xie,  Huizhong Chang, Wei He, Chunyan Wang, Chuanchao Dai,  Changfu Tian,  Xuebin Zhang,  Huan Liu*,  Ertao Wang*. Mycorrhizal symbiosis modulates the rhizosphere microbiota to promote rhizobia-legume symbiosis. Molecular Plant, 2021,14(3):503-516.

22. Dongsheng Chen, Jian Sun, Jiacheng Zhu, Xiangning Ding, Tianming Lan, Weiying Wu, Rong Xiang, Xiaoling Wang, Haoyu Wang, Peiwen Ding, Jiaying Qiu, Haimeng Li, Fuyu An, Le Zhang, Lei Han, Yixin Zhu, Haixia Chen, Dongming Fang, Yuying Zeng, Yiquan Wu, Qikai Feng, Feiyue Wang, Yuting Yuan, Wendi Wu, Xiran Wang, ZeHua Cui, Qian He,  Wei Qiu, Huanming Yang, Yan Hua*, Yahong Liu*, Huan Liu*, Xun Xu*. Single cell atlas for 11 non-model mammals, reptiles and birds. Nature Communications, 2021,12(1):7083.

23. Fei Chen, Liyao Su, Shuaiya Hu, Jiayu Xue, Hui Liu, Guanhua Liu, Yifan Jiang, Jianke Du, Yushan Qiao, Yannan Fan, Huan Liu, Qi Yang, Wenjie Lu, Zhu-Qing Shao, Jian Zhang, Liangsheng Zhang, Feng Chen, Zong-Ming (Max) Cheng.A chromosome-level genome assembly of rugged rose (Rosa rugosa) provides insights into its evolution, ecology, and floral characteristics. Horticulture Research, 2021,8:141.

24. Sibo Wang, Hongping Liang, Yan Xu, Linzhou Li, Hongli Wang, Durgesh Nandini Sahu, Morten Petersen, Michael Melkonian, Sunil Kumar Sahu, Huan Liu*. Genome-wide analyses across Viridiplantae reveal the origin and diversification of small RNA pathway-related genes. Communication Biology, 2021,4(1):412.

25. Tong Wei, Rob van Treuren, Xinjiang Liu, Ting Yang, Tianming Lan, Yang Liu, Zhaowu Zhang, Zhouquan Xiong, Shengping Han, Jinpu Wei, Haorong Lu, Jason C. Chen, Hanhui Kuang, Huanming Yang, Theo van Hintum, Xin Liu*, Huan Liu*. Whole-genome resequencing of 445 Lactuca accessions reveals the domestication history of cultivated lettuce. Nature Genetics, 2021,53:752760.

26. Shanshan Dong, Min Liu, Yang Liu, Fei Chen, Lu Chen, Xing Guo, Xingtan Zhang, Dongming Fang, Ting Yang, Linzhou Li, Tian Deng, Zhangxiu Yao, Xiaoan Lang, Ernest Wu, Yaling Wang, Yamei Shen, Xun Gong, Huan Liu*, Shouzhou Zhang*. The genome of Magnolia biondii Pamp. provides insights into the evolution of Magnoliales and biosynthesis of terpenoids. Horticulture Research, 2021,8:38.

27. Xuanmin Guang, Tianming Lan, Q. Wan, Yan Huang, Hong Li, Zhang Mingchun, Rengui Li, Zhizhong Zhang, Y. Lei, Ling Zhang, He-min Zhang, Desheng Li, Xiaoping Li, Haimeng Li, Yan Xu, Maiju Qiao, Daifu Wu, K. Tang, Peng Zhao, Jianzhang Lin, Sunil Kumar Sahu, Q. Liang, Wenkai Jiang, Danhui Zhang, Xun Xu, Xin Liu, M. Lisby, Huanming Yang, K. Kristiansen, Huan Liu*, Shengguo Fang*. Chromosome- scale genomes provide new insights into subspecies divergence and evolutionary characteristics of the giant panda, Science Bulletin, 2021,66(19):2002-2013.

28. Linzhou Li, Sibo Wang, Hongli Wang, Sunil Kumar Sahu, Birger Marin, Haoyuan Li, Yan Xu, Hongping Liang, Zhen Li, Shifeng Cheng, Tanja Reder, Zehra Çebi, Sebastian Wittek, Morten Petersen, Barbara Melkonian, Hongli Du, Huanming Yang, Jian Wang, Gane Ka-Shu Wong, Xun Xu, Xin Liu, Yves Van de Peer, Michael Melkonian*, Huan Liu*. The genome of Prasinoderma coloniale unveils the existence of a third phylum within green plants. Nature Ecology & Evolution, 2020,4:1220–1231.

29. Yannan Fan, Sunil Kumar Sahu, Ting Yang, Weixue Mu, Jinpu Wei, Le Cheng, Jinlong Yang, Ranchang Mu, Jie Liu, Jianming Zhao, Yuxian Zhao, Wang Jian, Xun Xu, Xin Liu, Huan Liu. Slicing the genome of star-fruit (Averrhoa carambola L.). Horticulture Research, 2020,7:94.

30. Sibo Wang, Linzhou Li, Haoyuan Li, Sunil Kumar Sahu, Hongli Wang, Yan Xu, Wenfei Xian, Bo Song, Hongping Liang,Shifeng Cheng,Yue Chang,Yue Song,Zehra Çebi,Sebastian Wittek, Tanja Reder, Morten Peterson, Huanming Yang, Jian Wang, Barbara Melkonian, Yves Van de Peer, Xun Xu, Gane Ka-Shu Wong, Michael Melkonian, Huan Liu*, Xin Liu*. The Genomes of early-diverging streptophyte algae shed light on plant terrestrialization. Nature Plants, 2020,6:95–106.

31. Yan Xu, Sibo Wang, Linzhou Li, Sunil Kumar Sahu, Morten Petersen, Xin Liu, Michael Melkonian, Gengyun Zhang, Huan Liu. Molecular evidence for origin, diversification and ancient gene duplication of plant subtilases (SBTs). Scientific Reports ,2019, 9:12485.

32. Tianming Lan, Yu Lin, Xiaosen Guo, Rengui Li, Jacob Ngatia, Haimeng Li, Xie Wang, Xiujuan Yang, Huabing Guo, Wenhao Xu, Karsten Kristiansen, Huan Liu, Yanchun Xu. An universal strategy to improve species identification of ancient animals based on next generation sequencing data. Genes, 2019, 10:509.

33. Shu-Heng Gan, Fan Yang, Sunil Kumar Sahu, Ruye Luo, Shui-Lin Liao, He-Yu Wang, Tao Jin, Li Wang, Peng-Fan Zhang, Xin Liu, Jin Xu, Jing Xu, Yayu Wang, Huan Liu. Deciphering the Taxonomy and Enzyme Profile of the Microbial Community in Chinese Moutai Liquor Starters. Front. Front Microbiol. 2019,10:1540.

34. Huan Liu, Tianming Lan, Dongming Fang, Furong Gui, Hongli Wang, Wei Guo, Xiaofang Cheng,View ORCID ProfileYue Chang, Shuqi He, Lihua Lyu,View ORCID ProfileSunil Kumar Sahu, Le Cheng, Haimeng Li, Ping Liu, Guangyi Fan, Tongxian Liu, Ruoshi Hao, Haorong Lu, Bin Chen, Shusheng Zhu, Zhihui Lu, Fangneng Huang, Wei Dong, Yang Dong, Le Kang, Huanming Yang, Jun Sheng, Youyong Zhu, Xin Liu. Chromosome level draft genomes of the fall armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae), an alien invasive pest in China. bioRxiv,2019.

35. Huan Liu, Jinpu Wei, Ting Yang , Weixue Mu, Bo Song, Tuo Yang, Yuan Fu, Xuebing Wang, Guohai Hu, Wangsheng Li, Hongcheng Zhou, Yue Chang, Xiaoli Chen, Hongyun Chen, Le Cheng, Xuefei He, Hechen Cai, Xianchu Cai, Mei Wang, Yang Li, Sunil Kumar Sahu , Jinlong Yang, Yu Wang, Ranchang Mu, Jie Liu, Jianming Zhao, Ziheng Huang, Xun Xu, Xin Liu. Molecular digitization of a botanical garden: high-depth whole-genome sequencing of 689 vascular plant species from the Ruili Botanical Garden. GigaScience, 2019,8(4):giz007.

36. Yue Chang#, Huan Liu#, Min Liu, Xuezhu Liao, Sunil Kumar Sahu, Yuan Fu, Bo Song, Shifeng Cheng, Robert Kariba, Samuel Muthemba, Prasad S Hendre, Sean Mayes, Wai Kuan Ho, Anna E J Yssel, Presidor Kendabie, Sibo Wang, Linzhou Li, Alice Muchugi, Ramni Jamnadass, Haorong Lu, Shufeng Peng, Allen Van Deynze, Anthony Simons, Howard Yana-Shapiro, Yves Van de Peer, Xun Xu, Huanming Yang, Jian Wang, Xin Liu. The draft genomes of five agriculturally important African orphan crops. GigaScience,2019,8(3):giy152.

37. Xuezhu Liao, Yang Liu, Huan Liu, The complete plastid genomes of two Fabaceae orphan crops from Africa, Mitochondrial DNA Part B. Resources, 2018,4(1):93-94.

38. Li Xiaoping, Liang Suisha, Xia Zhongkui, Qu Jing, Liu Huan, Liu Chuan, Yang Huanming, Wang Jian, Madsen Lise, Hou Yong, Li Junhua, Jia Huijue, Kristiansen Karsten, Xiao Liang .Establishment of a Macaca fascicularis gut microbiome gene catalog and comparison with the human, pig and mouse gut microbiomes, GigaScience, 2018, 7(9):1–10.

39. Hansheng Zhao, Shancen Zhao, International Network for Bamboo and Rattan, Benhua Fei, Huan Liu, Huanming Yang, Honghai Dai, Dan Wang, Wei Jin, Feng Tang, Qiang Gao, Hang Xun, Yuwei Wang, Lianghua Qi, Xianghua Yue, Shuyan Lin, Lianfeng Gu, Lubin Li, Tiansheng Zhu, Qiang Wei, Zhen Su, Tarmeze Bin Wanoup Ariffin Wan, Daniel A. Ofori, George Mbeva Muthike, Yigardu Mulatu Mengesha, Roberto Magno de Castro e Silva, Antonio Ludovico Beraldo, Zhimin Gao, Xin Liu, Zehui Jiang. Announcing the Genome Atlas of Bamboo and Rattan (GABR) project: promoting research in evolution and in economically and ecologically beneficial plants, GigaScience,2017, 6: 1-7.

40. Chunyang Du , Ming Wu , Huan Liu# , Yunzhuo Ren , Yunxia Du , Haijiang Wu , Jinying Wei , Chuxin Liu , Fang Yao , Hui Wang , Yan Zhu , Huijun Duan , Yonghong Shi .Thioredoxin-interacting protein regulates lipid metabolism via Akt/m TOR pathway in diabetic kidney disease. The International Journal of Biochemistry & Cell Biology,2016, 79:1-13.

41. Feida Li, Yong Li, Huan Liu#, Xingju Zhang, Chuxin Liu, Kai Tian, Lars Bolund, Hongwei Dou, Wenxian Yang, Huanming Yang, Nicklas Heine Staunstrup, Yutao Du.  Transgenic Wuzhishan minipigs designed to express a dominant‐negative porcine growth hormone receptor display short stature and a perturbed insulin/ IGF‐1 pathwayTransgenic Research, 2015 24:1029–1042.

42. Huan Liu, Yong Li ,Qiang Wei ,Chunxin Liu,Lars Bolund,Gábor Vajta,Hongwei Dou,Wenxian Yang,Ying Xu,Jing Luan,Jun Wang,Huanming Yang,Nicklas Heine Staunstrup ,Yutao Du.Development of Transgenic Minipigs with Expression of Antimorphic Human Cryptochrome 1. PLoS ONE,2013, 8(10): e76098.

43. Youcheng Lin, ZhaoYang, Abai Xu, Pei Dong, Yi Huang, Huan Liu, Feida Li, Haifeng Wang,Qian Xu, Yongqiang Wang, Da Sun, Yong Zou, Xiaowen Zou, Yu Wang, Duo Zhang, Hongjie Liu,Xun Wu, Meng Zhang, Yu Fu, Zhiming Cai, Chunxiao Liu, Song Wu.PIK3R1 negatively regulates the epithelial-mesenchymal transition and stem-like phenotype of renal cancer cells through the AKT/GSK3β/CTNNB1 signaling pathway, Scientific Reports, 2015,5:8997.


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